Glikolisis: Béda antarrépisi

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Baris ka-25:
Glikolisis mangrupakeun hiji-hijina jalur métabolik nu aya di ampir sakabéh organisme, hal ieu nunjukkeun kabuhunanana dina [[téori évolusi|posisi évolusi]]; diduga aya ti jaman [[prokariota]] munggaran, paling henteu 3,5 juta taun ka tukang.
 
==PathwayRuntuyan==
The<!--Hambalan firstkahiji stepdina inglikolisis glycolysis isnyaéta [[phosphorylationposporilasi]] ofglukosa glucose byku [[hexokinasehéksokinase]] (indina liver[[ati]] themah mosthéksikinase importantpangpentingna hexokinase istéh [[glucokinaseglukokinase]] which has slightly different properties than the hexokinases in most other cells). ThisRéaksi reactionieu consumesngahakan 1 molekul [[Adenosine triphosphate|ATP]] molecule, but the energy is well spent: although the [[plasma membrane|cell membrane]] is permeable to glucose because of the presence of glucose transport proteins, it is impermeable to glucose 6-phosphate. Glucose 6-phosphate is then rearranged into [[fructose]] 6-phosphate by phosphoglucose [[isomerase]]. (Fructose can also enter the [[glycolytic pathway]] at this point.)
 
[[Phosphofructokinase]]-1 then consumes 1 ATP to form fructose 1,6-bisphosphate. The energy expenditure in this step is justified in 2 ways: the glycolytic process (up to this step) is now irreversible, and the energy supplied to the molecule allows the ring to be split by [[aldolase]] into 2 molecules - dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. (Triosephosphate isomerase converts the molecule of dihydroxyacetone phosphate into a molecule of glyceraldehyde 3-phosphate.) Each molecule of glyceraldehyde 3-phosphate is then oxidized by a molecule of NAD<sup>+</sup> in the presence of glyceraldehyde 3-phosphate dehydrogenase, forming 1,3-bisphosphoglycerate.
Baris ka-34:
 
After the formation of fructose 1,6 bisphosphate, many of the reactions are energetically unfavorable. The only reactions that are favorable are the 2 substrate-level phosphorylation steps that result in the formation of ATP. These two reactions pull the glycolytic pathway to completion.
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==Étimologi==