Kortison

Kortison nyaéta hormon stériod prégnana (21-karbon) anu dikaluarkeun ku kelenjar adrénal dina nyanghareupan setrés. Sacara wangun kimia, ieu sanyawa kortikostéroid anu deukeut jeung kortisol. Kortison biasa dipaké natambaan rupa-rupa nyeri, ku cara neken sistem imun, ku kituna ngurangan peradangan/inflamasi anu dibarung ku nyeri jeung bareuh lebah nu tatu. Lamun dipaké terus-terusan, kortison bisa bahya ogé.

Kortison

Ngaran
Pronunciation	/ˈkɔːrtɪsoʊn/, /ˈkɔːrtɪzoʊn/
IUPAC name (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
Other names 17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone
Identifiers
CAS Number	53-06-5 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:16962 Y
ChEMBL	ChEMBL111861 N
ChemSpider	193441 Y
ECHA InfoCard	100.000.149
IUPHAR/BPS	5171
KEGG	D07749 Y
MeSH	Cortisone
PubChem <abbr title="<nowiki>Compound ID</nowiki>">CID	222786
CompTox Dashboard (<abbr title="<nowiki>U.S. Environmental Protection Agency</nowiki>">EPA)	DTXSID5022857
InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 Y Key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N Y InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 Key: MFYSYFVPBJMHGN-ZPOLXVRWBW
SMILES O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C
Pasipatan
Chemical formula	C21H28O5
Molar mass	360.450 g·mol−1
Melting point	220 to 224 °C (428 to 435 °F; 493 to 497 K)
Parmakologi
ATC code	H02AB10 (WHO) S01BA03 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Pangaruh jeung mangpaat

Kortison, glukokortikoid, jeung épinéfrin (adrénalin) ngaronjatkeun tekanan getih sarta nyiapkeun awa pikeun réspon lawan atawa ngejat.

Injéksi kortison bisa dipaké pikeun natambaan nyeri & bareuh saharitaeun dina peradangan sendi, urat, atawa bursa, upamana dina tuur, siku, jeung taktak.

Kortison ogé bisa dipaké pikeun ngurangan réspon imun jalma anu boga kasakit otoimun atawa nalika natambaan cangkok organ pikeun nyegah panolakan cangkokan. Suprési sistem imun ogé penting dina ngubaran kondisi peradangan.

Bacaeun salajengna

• Bonagura J., DVM et al. (2000). Current Veterinary Therapy 13. pp. 321–381. 
• Ingle DJ (October 1950). "The biologic properties of cortisone: a review". J. Clin. Endocrinol. Metab. 10 (10): 1312–54. doi:10.1210/jcem-10-10-1312. PMID 14794756. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=14794756. 
• Woodward R. B.; Sondheimer F.; Taub D. (1951). "The Total Synthesis of Cortisone". Journal of the American Chemical Society 73 (8): 4057. doi:10.1021/ja01152a551.