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Dijieun ku cara narjamahkeun kaca "Cortisone"

{| class="infobox bordered" style="border-collapse:collapse; width:22em; text-align:left; ;"
|+ id="5" style="text-align:center;" |Kortison
| colspan="2" style="text-align:center; padding:2px;" |[[File:Cortison.svg|220x220px]]
|-
| colspan="2" style="text-align:center; padding:2px;" |[[File:Cortisone-3D-balls.png|220x220px]]
|-
! colspan="2" style="background: #f8eaba; text-align: center;" |Ngaran
|-
|Pronunciation
|<span class="nowrap"><span class="IPA nopopups noexcerpt">[[Help:IPA/English|/<span style="border-bottom:1px dotted"><span title="/ˈ/: primary stress follows">ˈ</span><span title="'k' in 'kind'">k</span><span title="/ɔːr/: 'ar' in 'war'">ɔːr</span><span title="'t' in 'tie'">t</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="'s' in 'sigh'">s</span><span title="/oʊ/: 'o' in 'code'">oʊ</span><span title="'n' in 'nigh'">n</span></span>/]]</span></span>, <span class="nowrap"><span class="IPA nopopups noexcerpt">[[Help:IPA/English|/<span style="border-bottom:1px dotted"><span title="/ˈ/: primary stress follows">ˈ</span><span title="'k' in 'kind'">k</span><span title="/ɔːr/: 'ar' in 'war'">ɔːr</span><span title="'t' in 'tie'">t</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="'z' in 'zoom'">z</span><span title="/oʊ/: 'o' in 'code'">oʊ</span><span title="'n' in 'nigh'">n</span></span>/]]</span></span>
|-
| colspan="2" style="text-align:left;" |[[Chemical nomenclature|IUPAC name]]
<div style="max-width:22em; word-wrap:break-word; padding-left:1.7em;">(8''S'',9''S'',10''R'',13''S'',14''S'',17''R'')-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione</div>
|-
| colspan="2" style="text-align:left;" |Other names
<div style="max-width:22em; word-wrap:break-word; padding-left:1.7em;">17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone</div>
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! colspan="2" style="background: #f8eaba; text-align: center;" |Identifiers
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[CAS Registry Number|CAS Number]]</div>
|<div class="plainlist">
* <span title="www.commonchemistry.org">[http://www.commonchemistry.org/ChemicalDetail.aspx?ref=53-06-5 53-06-5]</span><sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup>
</div>
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|<div style="padding:0.1em 0;line-height:1.2em;">3D model ([[JSmol]])</div>
|<div class="plainlist">
* <span title="chemapps.stolaf.edu (3D interactive model)">[https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC%28CO%29%5BC%40%40%5D3%28O%29CC%5BC%40H%5D2%5BC%40%40H%5D4CC%5CC1%3DC%5CC%28%3DO%29CC%5BC%40%5D1%28C%29%5BC%40H%5D4C%28%3DO%29C%5BC%40%40%5D23C Interactive image]</span>
</div>
|-
|[[ChEBI]]
|<div class="plainlist">
* <span title="www.ebi.ac.uk">[https://www.ebi.ac.uk/chebi/searchId.do?chebiId=16962 CHEBI:16962]</span><sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup>
</div>
|-
|[[ChEMBL]]
|<div class="plainlist">
* <span title="www.ebi.ac.uk">[https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL111861 ChEMBL111861]</span><sup>&nbsp;[[File:X_mark.svg|pra=|alt=&#9746;|8x8px]]<span style="display:none">N</span></sup>
</div>
|-
|[[ChemSpider]]
|<div class="plainlist">
* <span title="www.chemspider.com">[http://www.chemspider.com/Chemical-Structure.193441.html 193441]</span><sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup>
</div>
|-
|[[ECHA InfoCard|<span title="echa.europa.eu">ECHA InfoCard</span>]]
|[https://echa.europa.eu/substance-information/-/substanceinfo/100.000.149 100.000.149]
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[IUPHAR/BPS]]</div>
|<div class="plainlist">
* <span title="www.guidetopharmacology.org">[http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=summary&ligandId=5171 5171]</span>
</div>
|-
|[[KEGG]]
|<div class="plainlist">
* <span title="www.kegg.jp">[http://www.kegg.jp/entry/D07749 D07749]</span><sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup>
</div>
|-
|[[Medical Subject Headings|MeSH]]
|<span title="www.nlm.nih.gov">[//www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?mode=&term=Cortisone Cortisone]</span>
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[PubChem]] <abbr title="<nowiki&gt;Compound ID</nowiki&gt;">CID</abbr></div>
|<div class="plainlist">
* <span title="pubchem.ncbi.nlm.nih.gov">[https://pubchem.ncbi.nlm.nih.gov/compound/222786 222786]</span>
</div>
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[CompTox Chemicals Dashboard|CompTox Dashboard]] <span style="font-weight:normal">(<abbr title="<nowiki&gt;U.S. Environmental Protection Agency</nowiki&gt;">EPA</abbr>)</span></div>
|<div class="plainlist">
* <span title="comptox.epa.gov">[https://comptox.epa.gov/dashboard/DTXSID5022857 DTXSID5022857] [[File:Blue_pencil.svg|pra=https://www.wikidata.org/wiki/Q423185#P3117|al=Edit this at Wikidata|atek|nirbing|10x10px|Edit this at Wikidata]]</span>
</div>
|-
| colspan="2" |<div class="NavFrame collapsed" style="border: none; padding: 0;">
<div class="NavHead" style="font-size: 105%; text-align:left; font-weight:normal; background:transparent;">[[International Chemical Identifier|InChI]]</div>

* <div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.5em; text-align:left;"><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1<sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup></div><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">Key:&nbsp;MFYSYFVPBJMHGN-ZPOLXVRWSA-N<sup>&nbsp;[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span></sup></div></div>
* <div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.5em; text-align:left;"><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1</div><div style="word-wrap:break-word; text-indent:-1.5em; font-size:11px; line-height:120%;">Key:&nbsp;MFYSYFVPBJMHGN-ZPOLXVRWBW</div></div>
</div>
|-
| colspan="2" |<div class="NavFrame collapsed" style="border: none; padding: 0;">
<div class="NavHead" style="font-size: 105%; text-align:left; font-weight:normal; background:transparent;">[[Simplified molecular-input line-entry system|SMILES]]</div>

* <div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.6em; word-wrap:break-word; text-indent:-1.5em; text-align:left; font-size:11px; line-height:120%;">O=C(CO)[C@@]3(O)CC[C@H]2[C@@H]4CC\C1=C\C(=O)CC[C@]1(C)[C@H]4C(=O)C[C@@]23C</div>
</div>
|-
! colspan="2" style="background: #f8eaba; text-align: center;" |Pasipatan
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[Chemical formula]]</div>
|<span title="Carbon">C</span><sub>21</sub><span title="Hydrogen">H</span><sub>28</sub><span title="Oxygen">O</span><sub>5</sub>
|-
|[[Molar mass]]
|<span class="nowrap">360.450</span>&nbsp;g·mol<sup>−1</sup> &#x20;
|-
|[[Melting point]]
|&#x20;220 to 224&nbsp;°C (428 to 435&nbsp;°F; 493 to 497&nbsp;K)&#x20;
|-
! colspan="2" style="background: #f8eaba; text-align: center;" |Parmakologi
|-
|<div style="padding:0.1em 0;line-height:1.2em;">[[Anatomical Therapeutic Chemical Classification System|ATC code]]</div>
|[[ATC code H02|H02AB10]]&#x20;(<span title="www.whocc.no">[https://www.whocc.no/atc_ddd_index/?code=H02AB10 WHO]</span>)&#x20;[[ATC code S01|S01BA03]]&#x20;(<span title="www.whocc.no">[https://www.whocc.no/atc_ddd_index/?code=S01BA03 WHO]</span>)
|-
| colspan="2" style="text-align:left; background:#f8eaba;" |<div style="margin:0 auto; text-align:left;"><div style="padding:0.1em 0;line-height:1.2em;">Except where otherwise noted, data are given for materials in their [[standard state]] (at 25&nbsp;°C [77&nbsp;°F], 100&nbsp;kPa).</div></div>
|- style="background:#f8eaba; border-top:2px solid transparent;"
| colspan="2" style="text-align:center;" |[[File:X_mark.svg|pra=|alt=&#9746;|14x14px]]<span style="display:none">N</span>&nbsp;<span class="reflink plainlinks nourlexpansion">[//en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=456660597&page2=Cortisone verify]</span>&nbsp;([[wikipedia:WikiProject_Chemicals/Chembox_validation|what is]]&nbsp;<sup>[[File:Yes_check.svg|pra=|alt=&#9745;|7x7px]]<span style="display:none">Y</span>[[File:X_mark.svg|pra=|alt=&#9746;|8x8px]]<span style="display:none">N</span></sup>&nbsp;?)
|- style="background:#f8eaba; border-top:2px solid transparent;"
| colspan="2" style="text-align:center;" |[[wikipedia:Chemical_infobox#References|Infobox&nbsp;references]]
|- style="background:#f8eaba;"
| style="width:40%; max-height:1px; border-top:2px solid transparent; border-right:1px solid transparent;" |
| style="width:60%; max-height:1px; border-top:2px solid transparent; border-left:1px solid transparent;" |
|}
[[Category:Articles containing unverified chemical infoboxes]]
'''Kortison''' nyaéta [[hormon stériod]] [[prégnana]] (21-karbon) anu dikaluarkeun ku [[kelenjar adrénal]] dina nyanghareupan setrés. Sacara wangun kimia, ieu sanyawa kortikostéroid anu deukeut jeung [[kortisol]]. Kortison biasa dipaké natambaan rupa-rupa nyeri, ku cara neken sistem imun, ku kituna ngurangan peradangan/inflamasi anu dibarung ku nyeri jeung bareuh lebah nu [[tatu]]. Lamun dipaké terus-terusan, kortison bisa bahya ogé. <ref name="mayo">{{Cite web|url=http://www.mayoclinic.com/health/cortisone-shots/MY00268|title=Cortisone shots|publisher=MayoClinic.com|accessdate=July 31, 2013}}</ref> <ref name="mayorisk2">{{Cite web|url=https://www.mayoclinic.org/steroids/art-20045692|title=Prednisone and other corticosteroids: Balance the risks and benefits|publisher=MayoClinic.com|accessdate=2017-12-21}}</ref>

== Pangaruh jeung mangpaat ==
Kortison, glukokortikoid, jeung [[Adrénalin|épinéfrin]] (adrénalin) ngaronjatkeun tekanan getih sarta nyiapkeun awa pikeun [[réspon lawan atawa ngejat]].

Injéksi kortison bisa dipaké pikeun natambaan nyeri & bareuh saharitaeun dina [[Inflamasi|peradangan]] sendi, urat, atawa bursa, upamana dina [[tuur]], [[siku]], jeung taktak.<ref name="mayo">{{Cite web|url=http://www.mayoclinic.com/health/cortisone-shots/MY00268|title=Cortisone shots|publisher=MayoClinic.com|accessdate=July 31, 2013}}</ref>

Kortison ogé bisa dipaké pikeun ngurangan réspon imun jalma anu boga kasakit otoimun atawa nalika natambaan cangkok organ pikeun nyegah panolakan cangkokan. Suprési sistem imun ogé penting dina ngubaran kondisi peradangan. <ref>{{Cite web|url=http://www.medicinenet.com/cortisone_injection/article.htm|title=Cortisone Injection (Corticosteroid Injection) of Soft Tissues & Joints|last=Driver|first=Catherine|last2=Shiel|first2=William|publisher=MedicineNet.com|accessdate=August 7, 2013}}</ref>

== Rujukan ==
{{Reflist|30em}}

== Bacaeun salajengna ==

* {{Cite book|last=Bonagura J., DVM|title=Current Veterinary Therapy|year=2000|pages=321–381|volume=13|display-authors=etal}}
* {{Cite journal|last=Ingle DJ|date=October 1950|title=The biologic properties of cortisone: a review|url=http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=14794756|journal=J. Clin. Endocrinol. Metab.|volume=10|issue=10|pages=1312–54|doi=10.1210/jcem-10-10-1312|pmid=14794756}}
* {{Cite journal|last=Woodward R. B.|last2=Sondheimer F.|last3=Taub D.|year=1951|title=The Total Synthesis of Cortisone|journal=Journal of the American Chemical Society|volume=73|issue=8|pages=4057|doi=10.1021/ja01152a551}}
{{Hormon}}
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