Triptopan

l-Triptopan
	; Rumus rangka L-triptopan
modél bal jeung tongkat	modél eusi rohang
Wasta
	Wasta IUPAC Tryptophan
	Wasta IUPAC sistematik asam (2S)-2-amino-3-(1H-indol-3-yl)propanoat
	Wasta lian Asam 2-amino-3-(1H-indol-3-il)propanoat
Pananda
Nomer CAS	73-22-3 ;
Modél 3D (JSmol)	Gambar interaktif; Zwitterion: Gambar interaktif;
ChEBI	CHEBI:16828;
ChEMBL	ChEMBL54976 ;
ChemSpider	6066 ;
DrugBank	DB00150 ;
ECHA InfoCard	100.000.723
IUPHAR/BPS	717;
KEGG	D00020 ;
PubChem CID	6305;
UNII	8DUH1N11BX ;
CompTox Dashboard (EPA)	DTXSID5021419 ;
	InChI InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 Key: QIVBCDIJIAJPQS-VIFPVBQESA-N ;
	SMILES c1[nH]c2ccccc2c1C[C@H](N)C(=O)O; Zwitterion: c1[nH]c2ccccc2c1C[C@H]([NH3+])C(=O)[O-];
Sipat
Rumus kimia	C11H12N2O2
Massa molar	204229 g·mol−1
Kelarutan dina cai	Leyur: 0.23 g/L at 0 °C,; 11.4 g/L at 25 °C,; 17.1 g/L at 50 °C,; 27.95 g/L at 75 °C
Solubilitas	Leyur dina alkohol panas, hidroksida alkali; teu leyur dina kloroform.
Kaasaman (pKa)	2.38 (karboksil), 9.39 (amino)
Suséptibilitas magnétik (χ)	-132.0·10−6 cm3/mol
Farmakologi
Kode ATC	N06AX02 (WHO)
	Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa).
	Rujukan kotak info

Triptopan (lambangna Trp atawa W)^[3] nyaéta asam α-amino anu dipaké dina biosintésis protéin. Triptopan ngandung hiji gugus α-amino, hiji gugus asam α-karboksilat, jeung hiji ranté gigir indol, ku kituna jadi molekul polar anu boga substituén karbon béta aromatik non-polar. Triptopan kaasup ésénsial pikeun manusa, anu hartina teu bisa disintésis/dijieun ku awak sorangan, kudu diala tina dahareun. Triptopan ogé mangrupa prékursor neurotransmiter serotonin, hormon mélatonin, jeung vitamin B3.^[4] Triptopan dikode ku kodon UGG.

Sakumaha asam amino lianna, triptopan ogé zwitterion dina pH pisiologis anu gugus aminona kaprotonan (–NH+3; pK_a = 9,39), anapon asam karboksilatna henteu ( –COO⁻; pK_a = 2,38).^[5]

Baca ogé édit

Rujukan édit

↑ ^a ^b Görbitz, C. H.; Törnroos, K. W.; Day, G. M. (2012). "Single-crystal investigation of L-tryptophan with Z′ = 16". Acta Crystallogr. B 68 (Pt 5): 549–557. doi:10.1107/S0108768112033484. PMID 22992800.
↑ Dawson RM et al. (1969). Data for Biochemical Research. Oxford: Clarendon Press. ISBN 0-19-855338-2.
↑ "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkan dari versi asli tanggal 9 October 2008. Diakses tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine
↑ "Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells". FEBS Letters 511 (1–3): 102–6. 2002. doi:10.1016/s0014-5793(01)03319-1. PMID 11821057.
↑ "L-tryptophan | C11H12N2O2 - PubChem". pubchem.ncbi.nlm.nih.gov. Diakses tanggal 22 December 2016.

Bacaan salajengna édit

"Effects of tryptophan depletion on the performance of an iterated Prisoner's Dilemma game in healthy adults". Neuropsychopharmacology 31 (5): 1075–84. May 2006. doi:10.1038/sj.npp.1300932. PMID 16407905.

Tutumbu kaluar édit

"KEGG PATHWAY: Tryptophan metabolism - Homo sapiens". KEGG: Kyoto Encyclopedia of Genes and Genomes. 2006-08-23. Diakses tanggal 2008-04-20.
G. P. Moss. "Tryptophan Catabolism (early stages)". Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Diarsipkan dari versi asli tanggal 2003-09-13. Diakses tanggal 2008-04-20.
G. P. Moss. "Tryptophan Catabolism (later stages)". Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Diarsipkan dari versi asli tanggal 2003-09-13. Diakses tanggal 2008-04-20.
B. Mikkelson; D. P. Mikkelson (2007-11-22). "Turkey Causes Sleepiness". Urban Legends Reference Pages. Snopes.com. Diakses tanggal 2008-04-20.

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Citakan:Intermédiat métabolisme neurotransmitter Citakan:Serotonérgika Citakan:Triptamina

[Görbitz-1] Görbitz, C. H.; Törnroos, K. W.; Day, G. M. (2012). "Single-crystal investigation of L-tryptophan with Z′ = 16". Acta Crystallogr. B 68 (Pt 5): 549–557. doi:10.1107/S0108768112033484. PMID 22992800.

[isbn0-19-855338-2-2] Dawson RM et al. (1969). Data for Biochemical Research. Oxford: Clarendon Press. ISBN 0-19-855338-2.

[3] "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkan dari versi asli tanggal 9 October 2008. Diakses tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine

[4] "Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells". FEBS Letters 511 (1–3): 102–6. 2002. doi:10.1016/s0014-5793(01)03319-1. PMID 11821057.

[PubChem-5] "L-tryptophan | C11H12N2O2 - PubChem". pubchem.ncbi.nlm.nih.gov. Diakses tanggal 22 December 2016.

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