Kortison
Kortison nyaéta hormon stériod prégnana (21-karbon) anu dikaluarkeun ku kelenjar adrénal dina nyanghareupan setrés. Sacara wangun kimia, ieu sanyawa kortikostéroid anu deukeut jeung kortisol. Kortison biasa dipaké natambaan rupa-rupa nyeri, ku cara neken sistem imun, ku kituna ngurangan peradangan/inflamasi anu dibarung ku nyeri jeung bareuh lebah nu tatu. Lamun dipaké matuh, kortison bisa bahya ogé. [1] [2]
Wasta | |
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Pronunciation | /ˈkɔːrtɪsoʊn/, /ˈkɔːrtɪzoʊn/ |
Wasta IUPAC
(8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
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Wasta lian
17α,21-Dihydroxypregn-4-ene-3,11,20-trione; 17α,21-Dihydroxy-11-ketoprogesterone; 17α-Hydroxy-11-dehydrocorticosterone
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Pananda | |
Modél 3D (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.149 |
KEGG | |
MeSH | Cortisone |
PubChem CID
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CompTox Dashboard (EPA)
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Sipat | |
C21H28O5 | |
Massa molar | 360450 g·mol−1 |
Titik lebur | 220 to 224 °C (428 to 435 °F; 493 to 497 K) |
Farmakologi | |
H02AB10 (WHO) S01 | |
Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa). | |
verifikasi (naon ieu ?) | |
Rujukan kotak info | |
Pangaruh jeung mangpaat
éditKortison, glukokortikoid, jeung épinéfrin (adrénalin) ngaronjatkeun tekanan getih sarta nyiapkeun awa pikeun réspon lawan atawa ngejat.
Injéksi kortison bisa dipaké pikeun natambaan nyeri & bareuh saharitaeun dina peradangan sendi, urat, atawa bursa, upamana dina tuur, siku, jeung taktak.[1]
Kortison ogé bisa dipaké pikeun ngurangan réspon imun jalma anu boga kasakit otoimun atawa nalika natambaan cangkok organ pikeun nyegah panolakan cangkokan. Suprési sistem imun ogé penting dina ngubaran kondisi peradangan. [3]
Rujukan
édit- ↑ a b "Cortisone shots". MayoClinic.com. Diakses tanggal July 31, 2013.
- ↑ "Prednisone and other corticosteroids: Balance the risks and benefits". MayoClinic.com. Diakses tanggal 2017-12-21.
- ↑ Driver, Catherine; Shiel, William. "Cortisone Injection (Corticosteroid Injection) of Soft Tissues & Joints". MedicineNet.com. Diakses tanggal August 7, 2013.
Bacaeun salajengna
édit- Bonagura J., DVM et al. (2000). Current Veterinary Therapy 13. pp. 321–381.
- Ingle DJ (October 1950). "The biologic properties of cortisone: a review". J. Clin. Endocrinol. Metab. 10 (10): 1312–54. doi:10.1210/jcem-10-10-1312. PMID 14794756. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=14794756.
- Woodward R. B.; Sondheimer F.; Taub D. (1951). "The Total Synthesis of Cortisone". Journal of the American Chemical Society 73 (8): 4057. doi:10.1021/ja01152a551.