Adrénalin



(R)-(–)-L-Epinéfrin atawa (R)-(–)-L-adrénalin
Ngaran sistimatik (IUPAC)
(R)-4-(1-hidroksi- 2-(métilamino)étil)bénzéna-1,2-diol
Identifiers
Nomer CAS	51-43-4
Sandi ATC	A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
PubChem	838
DrugBank	APRD00450
ChemSpider	5611
Data kimia
Rumus	C₉H₁₃N O₃
Mass. mol.	183.204 g/mol
Data farmakokinetik
Bioavailabilitas	Nil (oral)
Metabolisme	adrenergic synapse (MAO jeung COMT)
Waktu paruh	2 menit
Eksresi	Urin
Therapeutic considerations
Kat. kehamilan	A(AU) C(US)
Legal status	Prescription Only (S4)(AU) POM(UK) ?(US)
Jalur	IV, IM, éndotrahéa, IC

Epinéfrin (ogé katelah adrénalin; baca Terminologi) nyaéta hormon jeung neurotransmiter^[1] nu boga pancén dina réspon "lawan atawa ngejat" dina sistem saraf simpatétik^[2], hiji sanyawa katékolamina, monoamina simpatomimetik nu dihasilkeun ku kelenjar adrénal tina asam amino fénilalanin jeung tirosin.

Istilah épinéfrin diturunkeun tina akar basa Yunani epi- jeung nephros, nu hartina dina ginjal, nujul ka perenah anatomis kelenjarna. Akar basa Latén ad- jeung renes ngandung harti nu sarupa, ku kituna aya istilah adrénalin.

Kimiawan Jepang Jokichi Takamine jeung asisténna Keizo Uenaka sacara mandiri ngudar épinéfrin taun 1900^[3]^[4]. Taun 1901 Takamine bisa ngisolasi jeung ngamurnikeun ieu hormon tina kelenjar adrénal domba jeung sapi^[5]. Epinéfrin munggaran disintésis ku Friedrich Stolz jeung Henry Drysdale Dakin, séwang-séwangan taun 1904^[4].

Baca ogé

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Adrénalin

Rujukan

Catetan

↑ Berecek, K. H. and Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Heart and Circulatory Physiology 242 (4): H593-H601.
↑ Cannon, W. B. (1929). Am. J. Physiol. 89: 84-107.
↑ Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95–102. PMID 12717538.
↑ ^a ^b Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061.
↑ Takamine J (1901). The isolation of the active principle of the suprarenal gland. The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix–xxx.

Rujukan umum

Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach. Philadelphia, PA: Elsevier/Saunders. ISBN 1-4160-2328-3. OCLC 56191776.
Voet D, Voet J (2004). Biochemistry (3rd ed.). USA: Wiley. ISBN 0-471-19350-x Check |isbn= value (bantuan). OCLC 154657578.

[1] Berecek, K. H. and Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Heart and Circulatory Physiology 242 (4): H593-H601.

[2] Cannon, W. B. (1929). Am. J. Physiol. 89: 84-107.

[3] Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95–102. PMID 12717538.

[pmid10454061-4] Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061.

[5] Takamine J (1901). The isolation of the active principle of the suprarenal gland. The Journal of Physiology (Great Britain: Cambridge University Press). pp. xxix–xxx.

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