Métionin

Métionin
	; Rumus rangka bentuk kanonik métionin
Modél bal-jeung-tongkat	modél ngeusi-rohang
Wasta
	Wasta IUPAC Métionin
	Wasta lian Asam 2-amino-4-(métiltio)butanoat
Pananda
Nomer CAS	L: 63-68-3 ; D/L: 59-51-8 ; D: 348-67-4 ;
Modél 3D (JSmol)	L: Gambar interaktif; L Zwitterion: Gambar interaktif;
Abbreviations	Met, M
ChEBI	L: CHEBI:16643 ; D/L: CHEBI:16811 ; D: CHEBI:16867 ;
ChEMBL	L: ChEMBL42336 ;
ChemSpider	L: 5907 ; D/L: 853 ; D: 76512 ;
DrugBank	L: DB00134 ;
ECHA InfoCard	100.000.393
Nomer EC	200-432-1
KEGG	L: C00073 ;
PubChem CID	L: 6137; D/L: 876; D: 84815;
UNII	L: AE28F7PNPL ; D/L: 73JWT2K6T3 ; D: 868496F25R ;
CompTox Dashboard (EPA)	L: DTXSID9020821 ;
	InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 Key: FFEARJCKVFRZRR-BYPYZUCNSA-N ; D/L: Key: FFEARJCKVFRZRR-UHFFFAOYSA-N; D: Key: FFEARJCKVFRZRR-SCSAIBSYSA-N;
	SMILES L: CSCC[C@H](N)C(=O)O; L Zwitterion: CSCC[C@H]([NH3+])C(=O)[O-];
Sipat
Rumus kimia	C5H11NO2S
Massa molar	14921 g·mol−1
Panampilan	White crystalline powder
Dénsitas	1.340 g/cm3
Titik lebur	281 °C (538 °F; 554 K) decomposes
Kelarutan dina cai	Soluble
Kaasaman (pKa)	2.28 (carboxyl), 9.21 (amino)
Farmakologi
Kode ATC	V03AB26 (WHO) QA05BA90 (WHO), QG04BA90 (WHO)
	Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa).
	Rujukan kotak info

Métionin (lambangna Met atawa M)^[3] (/mɪˈθaɪəniːn/)^[4] nyaéta asam amino ésénsial pikeun manusa. Salaku prékursor asam amino sistéin jeung taurin, sanyawa multiguna sarupaning SAM-e, jeung antioksidan penting glutation, métionin mancén peran penting dina métabolisme jeung kaséhatan rupa-rupa spésiés.

Métionin ogé penting dina angiogenesis, tumuwuhna pembuluh getih. Supleméntasi métionin bisa natambaan anu karacunan tambaga.^[5] Sabalikna, asupan métionin anu kaleuleuwihi, donor gugus métil dina métilasi DNA, tumali jeung tumuwuhna kangker dina sababaraha panalungtikan.^[6]^[7] Métionin munggaran diisolasi taun 1921 ku John Howard Mueller.^[8]

Watek biokimia

Métionin (lambangna Met atawa M; dikode ku kodon AUG) téh asam α-amino anu dipaké dina biosintésis protéin. Ieu ngandung gugus karboksil (dina wangun kurang proton −COO⁻ dina kaayaan pH biologis), gugus amino (dina wangun leuwih proton −NH₃⁺ dina kaayaan pH biologis) dina α-posisi ti gugus karboksil, sarta ranté gigir S-métil tioéter, kagolongkeun kana asam amino nonpolar alipatik.

Dina gén inti eukariot jeung Archaea, métionin nyandi pikeun kodon mitembeyan, hartina nandaan ngamimitian daérah koding jeung asam amino munggaran anu diproduksi dina polipéptida nalika translasi mRNA.^[9]

Baca ogé

Rujukan

↑ Dawson RM, Elliott DC, Elliott WH, Jones KM (1959). Data for Biochemical Research. Oxford: Clarendon Press.
↑ Citakan:RubberBible62nd.
↑ "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkeun ti asli tanggal 9 October 2008. Diaksés tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine
↑ "Methionine". Oxford University Press. Archived 2018-01-27 di Wayback Machine
↑ "Methionine". WebMD.
↑ Cavuoto P, Fenech MF (2012). "A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension". Cancer Treatment Reviews. 38 (6): 726–36. doi:10.1016/j.ctrv.2012.01.004. PMID 22342103.
↑ Cellarier E, Durando X, Vasson MP, Farges MC, Demiden A, Maurizis JC, Madelmont JC, Chollet P (2003). "Methionine dependency and cancer treatment". Cancer Treatment Reviews. 29 (6): 489–99. doi:10.1016/S0305-7372(03)00118-X. PMID 14585259.
↑ Pappenheimer AM (1987). "A Biographical Memoir of John Howard Mueller" (PDF). Washington D.C.: National Academy of Sciences.
↑ Guedes RL, Prosdocimi F, Fernandes GR, Moura LK, Ribeiro HA, Ortega JM (December 2011). "Amino acids biosynthesis and nitrogen assimilation pathways: a great genomic deletion during eukaryotes evolution". BMC Genomics. 12 Suppl 4: S2. doi:10.1186/1471-2164-12-S4-S2. PMC 3287585. PMID 22369087. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

Tutumbu kaluar

Rudra MN, Chowdhury LM (30 September 1950). "Methionine Content of Cereals and Legumes". Nature. 166 (568): 568. Bibcode:1950Natur.166..568R. doi:10.1038/166568a0. PMID 14780151. S2CID 3026278.

[1] Dawson RM, Elliott DC, Elliott WH, Jones KM (1959). Data for Biochemical Research. Oxford: Clarendon Press.

[2] Citakan:RubberBible62nd.

[3] "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkeun ti asli tanggal 9 October 2008. Diaksés tanggal 5 March 2018. Archived 9 Oktober 2008 di Wayback Machine

[4] "Methionine". Oxford University Press. Archived 2018-01-27 di Wayback Machine

[5] "Methionine". WebMD.

[Cavuoto_2012-6] Cavuoto P, Fenech MF (2012). "A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension". Cancer Treatment Reviews. 38 (6): 726–36. doi:10.1016/j.ctrv.2012.01.004. PMID 22342103.

[Cellarier_2003-7] Cellarier E, Durando X, Vasson MP, Farges MC, Demiden A, Maurizis JC, Madelmont JC, Chollet P (2003). "Methionine dependency and cancer treatment". Cancer Treatment Reviews. 29 (6): 489–99. doi:10.1016/S0305-7372(03)00118-X. PMID 14585259.

[8] Pappenheimer AM (1987). "A Biographical Memoir of John Howard Mueller" (PDF). Washington D.C.: National Academy of Sciences.

[9] Guedes RL, Prosdocimi F, Fernandes GR, Moura LK, Ribeiro HA, Ortega JM (December 2011). "Amino acids biosynthesis and nitrogen assimilation pathways: a great genomic deletion during eukaryotes evolution". BMC Genomics. 12 Suppl 4: S2. doi:10.1186/1471-2164-12-S4-S2. PMC 3287585. PMID 22369087. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

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